2025-26 NFL Conference Winner Odds

Before reaching the Super Bowl, NFL teams must first win their respective conferences, allowing bettors to add more futures to their season-long portfolios. Placing wagers in this market can help bettors hedge their Super Bowl futures or add even more profit if they happen to place the right bets for both markets.

With the 2025-26 season inching closer, we’ll take a look at the odds of winning both the AFC and NFC across all legal sportsbooks in Louisiana.

2025-26 To Win the AFC - Best Odds Right Now

Odds as of July 18, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the AFC - Top10 Contenders

Odds as of July 18, 2025

Current Favorites

Kansas City Chiefs: The Chiefs have won the AFC five times since 2019. While they could not complete the Super Bowl three-peat, they opened as the favorite to win their fourth consecutive AFC title. While the Chiefs will still have Patrick Mahomes under center and a few more key players on defense, they certainly have a few areas to address this offseason, most notably their offensive line.

Buffalo Bills: Josh Allen took home the first MVP award of his career, but he was still unable to beat Patrick Mahomes in the AFC Championship. Buffalo seems to still be in their championship window, but they may need to upgrade a few areas of the team, including getting Josh Allen a true WR1.

Baltimore Ravens: The Ravens have failed to reach the Super Bowl in the Lamar Jackson era, and despite going 12-5 during the 2024-25 season, they were unable to advance past the AFC Championship game. Especially after acquiring Derrick Henry, the Ravens have continued to be a dominant regular-season team, but whether they can overcome the hump with Lamar Jackson remains to be determined.

Previous AFC Winners & Odds

2025-26 To Win the NFC - Current Best Odds

Odds as of July 18, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the NFC - Top10 Contenders

Odds as of July 18, 2025

Current Favorites

Philadelphia Eagles: For the second time since 2018, the Philadelphia Eagles were able to hoist the Lombardi Trophy. Behind their otherworldly defense and offense led by Saquon Barkley, the Eagles will enter next season as the team to beat in the NFL.

Detroit Lions: The best season for the Detroit Lions in decades ended with a disappointing loss at home in the NFC Divisional Round. Detroit was just unable to overcome the slew of injuries their defense suffered throughout the year. While the Lions will be returning a lot of star power, they will also be entering next season with a new offensive and defensive coordinator.

San Francisco 49ers: After winning the NFC in 2023, the 49ers put together a highly disappointing season in 2024, as they finished 6-11 and failed to even reach the postseason. San Francisco was bitten hard by the injury bug throughout the year, and there is a chance the team looks much different when week one of the 2025 season rolls around, as Deebo Samuel has left the team.

Past NFC Winners & Odds

AFC number 1 seed betting odds - TOP5 favorites

NFC number 1 seed odds - TOP5 favorites

Using DVOA and EPA to Time Conference Futures Bets

What a bettor values and analyzes for their futures bets is the difference between a quality winning bet and a losing bet. Sure, injuries and roster construction hold weight, but advanced metrics can often get overlooked by casual bettors, which causes them to miss out on value and hidden contenders that the market is overlooking. 

Two key advanced metrics that sharp bettors like to examine are EPA (Expected Points Added) and DVOA (Defense-adjusted Value Over Average). Since DVOA looks at how a team performs in comparison to the league average and adjusts for opponent strength, teams with average records at the start of the year that have a top-10 DVOA could be a team to look out for come the playoffs. 

One of the most important things that these stats offer is context, as they go beyond the box score to show efficiency on both sides of the ball. The 2024 season provided a strong glimpse of how valuable these stats can be. Through the first eight weeks of the season, the Washington Commanders' offense led the league in EPA per play, yet in Week 8, they were still (+1400) to win the NFC. 

While they didn’t win the NFC, they still provided sharp bettors who take advantage of the market not adjusting a valuable hedging opportunity.

Related articles & NFL betting resources

• 2025-26 NFL MVP Odds

• 2025-26 NFL Player of the Year Odds

• 2025-26 NFL Coach of the Year Odds

• 2025-26 NFL Rookie of the Year Odds

• 2025-26 NFL Comeback Player Of The Year Odds

• 2025-26 NFL Stat Leader Odds | Passing, Rushing & Receiving

• 2025 NFL Draft Betting Odds

• 2026 Super Bowl LX Betting Odds

• 2024-25 NFL Divisional Winner Odds

• Odds to Make the 2024-25 NFL Playoffs