2025-26 NFL Conference Winner Odds

Before reaching the Super Bowl, NFL teams must first win their respective conferences, allowing bettors to add more futures to their season-long portfolios. Placing wagers in this market can help bettors hedge their Super Bowl futures or add even more profit if they happen to place the right bets for both markets.

With the 2025-26 season entering Week 13, we’ll take a look at the odds of winning both the AFC and NFC across all legal sportsbooks in Louisiana.

2025-26 To Win the AFC - Best Odds Right Now

Odds as of November 26, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the AFC - Top10 Contenders

Odds as of November 26, 2025

Current Favorites

Indianapolis Colts: The Colts were a big question mark before the season, as fans tried to determine whether the team would stick with Anthony Richardson or give Daniel Jones a shot. Ultimately, the team decided on Jones, and early this season, that had proven to be a wise decision. Indianapolis has started the year 8-3 and, even after a tough overtime loss to the Chiefs, is ranked first in EPA per play and second in offensive success rate, according to RBSDM.

Kansas City Chiefs: After starting the year 0-2, the Chiefs grinded out a win over the Giants in Week Three, and for a while after, returned to their juggernaut form. Following that win over New York, the Chiefs went 5-2 over their next seven games, before suffering another two-game losing streak. With their backs against the wall and sitting at 5-5, the Chiefs rallied back to beat the Colts at home, proving they still can win close games against fellow playoff-level opponents.

New England Patriots: Ever since they beat the Bills early in the season, the New England Patriots have not looked back. With Drake Maye playing at an MVP-caliber level in just his second NFL season, the Patriots have found success a lot quicker than many expected, as their 10-2 record has them sitting in first place in the AFC East. Behind Maye on offense, the Patriots rank 7th in EPA per play, while new head coach Mike Vrabel has helped guide the defense to be ranked 6th in EPA per play, per RBSDM.

Previous AFC Winners & Odds

2025-26 To Win the NFC - Current Best Odds

Odds as of November 26, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the NFC - Top10 Contenders

Odds as of November 26, 2025

Current Favorites

Los Angeles Rams: Aside from two losses by one possession, the LA Rams have played at a nearly flawless level. With Matthew Stafford continuing to play at an MVP-caliber level and their defense ranking first in the league in EPA per play, the Rams have asserted their dominance on both sides of the ball. Following a win over the Buccaneers, the Rams now have sole possession of first place in the NFC West and the best point differential in the league (+127).

Philadelphia Eagles: For the second time since 2018, the Philadelphia Eagles were able to hoist the Lombardi Trophy. Behind their otherworldly defense and offense led by Saquon Barkley, the Eagles entered this season as the team to beat in the NFC. The Eagles took care of business through the first four weeks, beating the Cowboys, Chiefs, Rams, and Buccaneers. However, despite those wins, there were reasonable concerns about their offensive production. While the Eagles' offense and how they use certain players remain a weekly topic, their defense helped them win four straight games before suffering a loss to the Cowboys.

Detroit Lions: It was shocking to see how quickly some people were willing to press the panic button on the Lions after a Week One loss to the Packers. Detroit's offense without Ben Johnson calling the plays was a topic of conversation heading into Week Two, but it did not take long for the Lions to put those comments to bed, as they ran the score up on the Bears in a game that saw Jared Goff throw five touchdowns. Detroit is 4-3 over their last seven games following an overtime win over the Giants, and with that, they rank 8th in offensive EPA per play and 9th in defensive EPA per play, per RBSDM.

Past NFC Winners & Odds

AFC number 1 seed betting odds - TOP5 favorites

NFC number 1 seed odds - TOP5 favorites

Using DVOA and EPA to Time Conference Futures Bets

What a bettor values and analyzes for their futures bets is the difference between a quality winning bet and a losing bet. Sure, injuries and roster construction hold weight, but advanced metrics can often get overlooked by casual bettors, which causes them to miss out on value and hidden contenders that the market is overlooking. 

Two key advanced metrics that sharp bettors like to examine are EPA (Expected Points Added) and DVOA (Defense-adjusted Value Over Average). Since DVOA looks at how a team performs in comparison to the league average and adjusts for opponent strength, teams with average records at the start of the year that have a top-10 DVOA could be a team to look out for come the playoffs. 

One of the most important things that these stats offer is context, as they go beyond the box score to show efficiency on both sides of the ball. The 2024 season provided a strong indication of the value these statistics can bring. Through the first eight weeks of the season, the Washington Commanders' offense led the league in EPA per play, yet in Week 8, they were still (+1400) to win the NFC. 

While they didn’t win the NFC, they still provided sharp bettors who took advantage of the market not adjusting to a valuable hedging opportunity.

Related articles & NFL betting resources

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• 2026 Super Bowl LX Betting Odds

• 2025-26 NFL Divisional Winner Odds

• Odds to Make the 2025-26 NFL Playoffs