2025-26 NFL Conference Winner Odds

Before reaching the Super Bowl, NFL teams must first win their respective conferences, allowing bettors to add more futures to their season-long portfolios. Placing wagers in this market can help bettors hedge their Super Bowl futures or add even more profit if they happen to place the right bets for both markets.

With the 2025-26 season entering Week Ten, we’ll take a look at the odds of winning both the AFC and NFC across all legal sportsbooks in Louisiana.

2025-26 To Win the AFC - Best Odds Right Now

Odds as of November 5, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the AFC - Top10 Contenders

Odds as of November 5, 2025

Current Favorites

Buffalo Bills: Josh Allen took home the first MVP award of his career during the 2024-25 season, but he was still unable to beat Patrick Mahomes in the AFC Championship. Their ability to get over the hump remains the biggest question. Early in the season, the Bills certainly looked like Super Bowl contenders, having opened the year 4-1. After losing two straight games with poor defensive efforts, the Bills have bounced back with wins over the Panthers and Chiefs.

Kansas City Chiefs: Even when all hope seems lost, the Kansas City Chiefs find a way. After starting the year 0-2, the Chiefs grinded out a win over the Giants in Week Three, and have since returned to their juggernaut form. Following that win over New York, the Chiefs have gone 5-2 over their last seven games, and despite losing to the Bills in Week Nine, they still rank 4th in the league in EPA per play on offense, per RBSDM.

Indianapolis Colts: The Colts were a big question mark before the season, as fans tried to determine whether the team would stick with Anthony Richardson or give Daniel Jones a shot. Ultimately, the team decided on Jones, and early this season, that had proven to be a wise decision. Indianapolis has started the year 7-2 and is ranked first in EPA per play and second in offensive success rate, according to RBSDM.

Previous AFC Winners & Odds

2025-26 To Win the NFC - Current Best Odds

Odds as of November 5, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the NFC - Top10 Contenders

Odds as of November 5, 2025

Current Favorites

Philadelphia Eagles: For the second time since 2018, the Philadelphia Eagles were able to hoist the Lombardi Trophy. Behind their otherworldly defense and offense led by Saquon Barkley, the Eagles entered this season as the team to beat in the NFC. The Eagles took care of business through the first four weeks, beating the Cowboys, Chiefs, Rams, and Buccaneers. However, despite those wins, there were reasonable concerns about their offensive production. Well, it did not take long for those concerns to come to fruition, as Philadelphia suffered two straight losses before getting back on track with wins over the Vikings and Giants.

Los Angeles Rams: Aside from two losses by one possession, the LA Rams have played at a nearly flawless level. With Matthew Stafford continuing to play at an MVP-caliber level and their defense leading the league in EPA per play, the Rams have asserted their dominance on both sides of the ball. As a result, LA is not only tied for first in the NFC West but also has the best point differential in the NFC.

Detroit Lions: It was shocking to see how quickly some people were willing to press the panic button on the Lions after a Week One loss to the Packers. Detroit's offense without Ben Johnson calling the plays was a topic of conversation heading into Week Two, but it did not take long for the Lions to put those comments to bed, as they ran the score up on the Bears in a game that saw Jared Goff throw five touchdowns. Detroit has since followed that up by going 4-2 over their last six games, and despite losing to Minnesota in Week Nine, they still rank inside the top ten in EPA per play on both sides of the ball (RDSDM).

Past NFC Winners & Odds

AFC number 1 seed betting odds - TOP5 favorites

NFC number 1 seed odds - TOP5 favorites

Using DVOA and EPA to Time Conference Futures Bets

What a bettor values and analyzes for their futures bets is the difference between a quality winning bet and a losing bet. Sure, injuries and roster construction hold weight, but advanced metrics can often get overlooked by casual bettors, which causes them to miss out on value and hidden contenders that the market is overlooking. 

Two key advanced metrics that sharp bettors like to examine are EPA (Expected Points Added) and DVOA (Defense-adjusted Value Over Average). Since DVOA looks at how a team performs in comparison to the league average and adjusts for opponent strength, teams with average records at the start of the year that have a top-10 DVOA could be a team to look out for come the playoffs. 

One of the most important things that these stats offer is context, as they go beyond the box score to show efficiency on both sides of the ball. The 2024 season provided a strong indication of the value these statistics can bring. Through the first eight weeks of the season, the Washington Commanders' offense led the league in EPA per play, yet in Week 8, they were still (+1400) to win the NFC. 

While they didn’t win the NFC, they still provided sharp bettors who took advantage of the market not adjusting to a valuable hedging opportunity.

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