2025-26 NFL Conference Winner Odds

Before reaching the Super Bowl, NFL teams must first win their respective conferences, allowing bettors to add more futures to their season-long portfolios. Placing wagers in this market can help bettors hedge their Super Bowl futures or add even more profit if they happen to place the right bets for both markets.

With the 2025-26 season entering Week 14, we’ll take a look at the odds of winning both the AFC and NFC across all legal sportsbooks in Louisiana.

2025-26 To Win the AFC - Best Odds Right Now

Odds as of December 3, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the AFC - Top10 Contenders

Odds as of December 3, 2025

Current Favorites

New England Patriots: Ever since they beat the Bills early in the season, the New England Patriots have not looked back. With Drake Maye playing at an MVP-caliber level in just his second NFL season, the Patriots have found success a lot quicker than many expected, as their 11-2 record has them sitting in first place in the AFC East. Behind Maye on offense, the Patriots rank 12th in success rate, while new head coach Mike Vrabel has helped guide the defense to be ranked 7th in EPA per play, per RBSDM.

Buffalo Bills: The Bills have been all over the odds board this season. Every time it seems like they are garnering momentum, they suffer a surprising loss, and on the flip side, when it looks like they are trending down, Josh Allen saves the day and gets them back in the win column. The past four weeks have been a perfect example of that, as they have lost games to the Dolphins and Texans, only to turn around and beat the Buccaneers and Steelers. With their defense ranked 10th in success rate and Josh Allen leading the offense, the only thing missing is consistency.

Denver Broncos: In year two of the Bo Nix era, the Broncos look well on their way to ending the Chiefs' longstanding streak of winning the AFC West. After an overtime win over the Commanders, the Broncos have won nine straight games, giving them a 10-2 record. While Nix has been solid in his sophomore season, Denver's true calling card is their defense, which ranks 5th in EPA per play and 1st in success rate (RBSDM).

Previous AFC Winners & Odds

2025-26 To Win the NFC - Current Best Odds

Odds as of December 3, 2025

* = the same odds are offered by multiple sportsbooks.

2025-26 Odds to Win the NFC - Top10 Contenders

Odds as of December 3, 2025

Current Favorites

Los Angeles Rams: Aside from three losses by one possession, the LA Rams have played at a nearly flawless level. With Matthew Stafford continuing to play at an MVP-caliber pace and their defense ranking second in the league in EPA per play, the Rams have asserted their dominance on both sides of the ball. Even after a loss to the Panthers, the Rams still hold first place in the NFC West and the second-best point differential in the league (+124).

Seattle Seahawks: The Seahawks have been a competitive team over the past few seasons, and especially since Mike Macdonald took over. However, their ceiling, especially on offense, has been raised by having Sam Darnold under center. With Darnold proving last season in Minnesota was not a fluke, and the Seahawks' defense ranking 4th in success rate, Seattle has the best point differential in the league (+133) to go with their 9-3 record.

Philadelphia Eagles: For the second time since 2018, the Philadelphia Eagles were able to hoist the Lombardi Trophy. Behind their otherworldly defense and offense led by Saquon Barkley, the Eagles entered this season as the team to beat in the NFC. The Eagles took care of business through the first four weeks, beating the Cowboys, Chiefs, Rams, and Buccaneers. However, despite those wins, there were reasonable concerns about their offensive production. Entering Week 14, those concerns have led to plenty of questions about why Kevin Patullo still has play-calling duties after the Eagles dropped their second straight game to the Bears.

Past NFC Winners & Odds

AFC number 1 seed betting odds - TOP5 favorites

NFC number 1 seed odds - TOP5 favorites

Using DVOA and EPA to Time Conference Futures Bets

What a bettor values and analyzes for their futures bets is the difference between a quality winning bet and a losing bet. Sure, injuries and roster construction hold weight, but advanced metrics can often get overlooked by casual bettors, which causes them to miss out on value and hidden contenders that the market is overlooking. 

Two key advanced metrics that sharp bettors like to examine are EPA (Expected Points Added) and DVOA (Defense-adjusted Value Over Average). Since DVOA looks at how a team performs in comparison to the league average and adjusts for opponent strength, teams with average records at the start of the year that have a top-10 DVOA could be a team to look out for come the playoffs. 

One of the most important things that these stats offer is context, as they go beyond the box score to show efficiency on both sides of the ball. The 2024 season provided a strong indication of the value these statistics can bring. Through the first eight weeks of the season, the Washington Commanders' offense led the league in EPA per play, yet in Week 8, they were still (+1400) to win the NFC. 

While they didn’t win the NFC, they still provided sharp bettors who took advantage of the market not adjusting to a valuable hedging opportunity.

Related articles & NFL betting resources

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• 2026 Super Bowl LX Betting Odds

• 2025-26 NFL Divisional Winner Odds

• Odds to Make the 2025-26 NFL Playoffs